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FDA Disclaimer: The content and products mentioned on this website have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold exclusively for research, laboratory, or analytical purposes and are not intended for human consumption. The information provided is strictly for informational purposes only. All products are sold for research, laboratory, or analytical purposes only, and are not for human consumption. PRODUCTS ARE NOT FOR RESALE.
PE-22-28_RUO 10mg
PE-22-28_RUO 10mg - Image 2

PE-22-28_RUO 10mg

Price range: $60.00 through $500.00

PE-22-28 10mg is a synthetic heptapeptide (7-amino-acid) analog of spadin (a naturally occurring peptide fragment from the sortilin propeptide), optimized as a potent and selective inhibitor of the TREK-1 (TWIK-related K⁺ channel 1, also known as KCNK2) two-pore domain potassium channel.
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SKU: PP-203 Category:

PE-22-28 10mg is a synthetic heptapeptide (7-amino-acid) analog of spadin (a naturally occurring peptide fragment from the sortilin propeptide), optimized as a potent and selective inhibitor of the TREK-1 (TWIK-related K⁺ channel 1, also known as KCNK2) two-pore domain potassium channel. With an reported IC₅₀ of approximately 0.12 nM, this shortened sequence exhibits enhanced potency, stability, and specificity compared to the parent spadin (PE 12-28). The sequence is Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR), with a molecular formula of C₃₅H₅₅N₁₁O₉ and a molecular weight of approximately 773.88–773.9 Da (variations noted across sources due to exact form or acetate salt). Supplied as high-purity lyophilized powder (>98% purity, verified by HPLC and mass spectrometry), PE-22-28 is intended exclusively for research and scientific experimentation.

Critical Notice – For Research Use Only
This product is sold strictly for laboratory research and scientific experimentation by qualified professionals. It is not approved by the FDA or any regulatory agency for human consumption, medical treatment, diagnostic use, veterinary application, food additive, cosmetic ingredient, or performance enhancement. It is not a drug, dietary supplement, or therapeutic agent. Any off-label or non-research use is strictly prohibited and may violate applicable federal, state, or local laws (including the Federal Food, Drug, and Cosmetic Act). By purchasing, the buyer acknowledges and agrees that the product will be used solely for lawful research purposes in a controlled laboratory setting. Handle with appropriate safety precautions; consult institutional guidelines and regulations.

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