FOXO 4 – RUO 10mg

FOXO4-DRI 10mg (also known as FOXO4-D-Retro-Inverso or Proxofim) is a synthetic, cell-permeable peptide designed as a D-retro-inverso (DRI) analog mimicking a key interaction domain of the Forkhead box protein O4 (FOXO4) transcription factor. This modification uses all D-amino acids in reverse sequence order for enhanced enzymatic stability, resistance to proteolysis, and improved cellular penetration in research models. The sequence is H-ltlrkepaseiaqsileaysqngwanrrsggkrppprrrqrrkkrg-OH (all D-enantiomer retro-inverso form), with a molecular formula of C₂₂₈H₃₈₈N₈₆O₆₄ and a molecular weight of approximately 5358 Da (often reported as 5358.05–5358.06 g/mol). Supplied as high-purity lyophilized powder (>98% purity, verified by HPLC and mass spectrometry), FOXO4-DRI is intended exclusively for in vitro research and scientific experimentation. It is commonly utilized in preclinical laboratory models to investigate disruption of FOXO4-p53 protein-protein interactions, mechanisms of selective induction of apoptosis in senescent cells (via p53 nuclear exclusion and mitochondrial redirection), clearance of senescent (“zombie”) cells, modulation of cellular senescence pathways, tissue homeostasis restoration, chemotoxicity neutralization (e.g., doxorubicin-induced models), and related processes in cellular assays (e.g., fibroblasts, organotypic cultures), tissue models, or animal systems exploring aging dynamics, age-related dysfunction (e.g., renal, vascular, hormonal), neurodegeneration, cancer cell senescence, and regenerative biology.