Semaglutide – Research Use Only
Semaglutide is a synthetic 31-amino acid peptide analog of human glucagon-like peptide-1 (GLP-1). It features two key modifications compared to native GLP-1(7-37): substitution of alanine at position 8 with α-aminoisobutyric acid (Aib) for enhanced resistance to dipeptidyl peptidase-4 (DPP-4) degradation, and acylation of the lysine residue at position 26 with a C18 fatty diacid (stearic diacid) via a spacer consisting of two 8-amino-3,6-dioxaoctanoic acid (ADO) moieties and a glutamic acid linker. An additional arginine substitution occurs at position 34.
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: 4113.58 Da (average) / 4111.12 Da (monoisotopic)
CAS Number: 910463-68-2
Purity: ≥98% (third-party HPLC verified – COA available upon request)
Appearance: Lyophilized white to off-white powder
Solubility: Soluble in DMSO or sterile water for laboratory reconstitution protocols
In controlled laboratory and in vitro research settings, Semaglutide is studied as a potent GLP-1 receptor agonist. Investigations have explored its binding affinity, receptor signaling pathways, metabolic stability, and effects in various cellular and animal models of metabolic research.
Semaglutide-RUO 10mg
Price range: $80.00 through $550.00
Semaglutide – Research Use Only
Semaglutide is a synthetic 31-amino acid peptide analog of human glucagon-like peptide-1 (GLP-1). It features two key modifications compared to native GLP-1(7-37): substitution of alanine at position 8 with α-aminoisobutyric acid (Aib) for enhanced resistance to dipeptidyl peptidase-4 (DPP-4) degradation
About More
For Research Use Only (RUO).
This product is intended strictly for laboratory and scientific research purposes. It is not for human consumption, diagnostic use, therapeutic use, or any veterinary application. All research must comply with applicable institutional review board (IRB) guidelines and local regulations. Profound Peptides assumes no responsibility for any use outside of controlled laboratory conditions.
Storage: Store lyophilized peptide at -20°C. Reconstituted solutions should be used promptly or stored appropriately per validated lab protocols.
Handling: Use appropriate personal protective equipment and follow standard laboratory safety practices when handling peptides.






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