TB-500_RUO 10mg

TB-500 10mg (Thymosin Beta-4 fragment, also known as fequesetide or Ac-LKKTETQ) is a synthetic heptapeptide corresponding to the N-acetylated active fragment (amino acids 17–23) of the naturally occurring thymosin beta-4 (Tβ4) protein. This 7-amino-acid sequence is Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ), with a molecular formula of C₃₈H₆₈N₁₀O₁₄ and a molecular weight of approximately 889.01–889.02 Da. The N-terminal acetylation enhances stability and resistance to degradation compared to the non-acetylated form (LKKTETQ), making it suitable for controlled laboratory investigations into actin-binding domains and related cellular processes. Supplied as high-purity lyophilized powder (>98% purity, verified by HPLC and mass spectrometry), TB-500 is intended exclusively for in vitro research and scientific experimentation. It is commonly utilized in preclinical laboratory models to investigate actin sequestration and regulation mechanisms, cell migration and differentiation pathways, extracellular matrix remodeling, angiogenesis promotion, wound healing dynamics, anti-inflammatory signaling, tissue repair processes (e.g., in musculoskeletal, dermal, or corneal models), and related biochemical cascades in cellular assays (e.g., endothelial cells, fibroblasts, keratinocytes), tissue cultures, or animal systems exploring regenerative biology, injury recovery models, inflammation modulation, and cytoskeletal dynamics.