KPV_RUO 10mg

KPV 10mg (Lys-Pro-Val) is a synthetic tripeptide corresponding to the C-terminal fragment (amino acids 11-13) of alpha-melanocyte-stimulating hormone (α-MSH). This short, stable peptide retains key immunomodulatory properties of the parent hormone without melanotropic (pigment-inducing) effects or direct melanocortin receptor activation in many models. The sequence is Lys-Pro-Val (L-Lysyl-L-Prolyl-L-Valine), with a molecular formula of C₁₆H₃₀N₄O₄ and a molecular weight of approximately 342.43–342.44 Da (monoisotopic mass; slight variations noted across sources due to exact protonation states).
Supplied as high-purity lyophilized powder (>98% purity, verified by HPLC and mass spectrometry), KPV is intended exclusively for in vitro research and scientific experimentation. It is commonly utilized in preclinical laboratory models to investigate anti-inflammatory signaling pathways (e.g., inhibition of NF-κB activation and nuclear translocation, suppression of pro-inflammatory cytokine production such as TNF-α, IL-1β, and IL-6), PepT1-mediated cellular uptake mechanisms in epithelial cells, immune modulation, mucosal barrier protection, wound healing dynamics, and related processes in cellular assays (e.g., keratinocytes, intestinal epithelial cells, microglia), tissue models, or animal systems exploring inflammatory conditions (e.g., colitis, dermatitis, airway inflammation), epithelial integrity, and resolution of inflammatory responses.